{"product_id":"semax","title":"Semax","description":"\u003cdiv class=\"prod-section\"\u003e\n    \u003cdiv class=\"prod-section-label\"\u003e\n        \u003ci class=\"ti ti-file-description\"\u003e\u003c\/i\u003eResearch Background\n    \u003c\/div\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        Semax (CAS 80714-61-0; MW 887.0 g\/mol; sequence MEHFPGP) is a synthetic 7-amino acid heptapeptide derived from the 4th through 7th amino acids of adrenocorticotropic hormone (ACTH) — the ACTH(4-7) fragment (Met-Glu-His-Phe) — with a C-terminal Pro-Gly-Pro tripeptide extension appended to confer enzymatic resistance against proteolytic degradation, substantially extending biologically active half-life while preserving nootropic properties without ACTH's adrenocortical hormonal activity.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        Semax has undergone extensive clinical investigation in Russia, where it is approved as a nootropic and neuroprotective medication for ischemic stroke sequelae, transient ischemic attacks, and cognitive impairment states — providing a richer translational context than purely experimental compounds.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        The primary and best-characterized mechanism is BDNF (Brain-Derived Neurotrophic Factor) upregulation. Multiple research and clinical studies document Semax's ability to rapidly and substantially increase BDNF expression and its high-affinity receptor TrkB in cortical, hippocampal, and striatal brain regions. BDNF is essential for synaptic plasticity, long-term potentiation, learning and memory consolidation, and neuronal survival under stress.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        Simultaneously, Semax upregulates NGF and activates dopaminergic, serotonergic, and cholinergic neurotransmitter systems — producing measurable improvements in attention, memory encoding, and cognitive speed in research model and human studies.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        In neuroprotection research, Semax has demonstrated significant efficacy in research subject ischemia\/reperfusion models, reducing infarct volume, improving neurological deficit scores, and enhancing post-ischemic recovery. The 25mg vial format reflects Semax research utility in extended protocols, multi-animal studies, and intranasal delivery model preparation.\n    \u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"prod-section\"\u003e\n    \u003cdiv class=\"prod-section-label\"\u003e\n        \u003ci class=\"ti ti-atom\"\u003e\u003c\/i\u003ePhysicochemical Data\n    \u003c\/div\u003e\n\n    \u003cdiv class=\"table-scroll\"\u003e\n        \u003ctable class=\"prod-table\"\u003e\n            \u003cthead\u003e\n                \u003ctr\u003e\n                    \u003cth\u003eCompound\u003c\/th\u003e\n                    \u003cth\u003eFormula\u003c\/th\u003e\n                    \u003cth\u003eMW\u003c\/th\u003e\n                    \u003cth\u003eCAS No.\u003c\/th\u003e\n                    \u003cth\u003eSequence \/ Structure\u003c\/th\u003e\n                    \u003cth\u003eReceptor \/ Target\u003c\/th\u003e\n                \u003c\/tr\u003e\n            \u003c\/thead\u003e\n\n            \u003ctbody\u003e\n                \u003ctr class=\"row-alt\"\u003e\n                    \u003ctd class=\"td-bold\"\u003eSemax\u003c\/td\u003e\n                    \u003ctd\u003eC37H51N9O10S\u003c\/td\u003e\n                    \u003ctd\u003e887.0 g\/mol\u003c\/td\u003e\n                    \u003ctd\u003e80714-61-0\u003c\/td\u003e\n                    \u003ctd\u003eMEHFPGP — ACTH(4-7) fragment + Pro-Gly-Pro extension\u003c\/td\u003e\n                    \u003ctd\u003eBDNF\/NGF upregulator; dopaminergic\/serotonergic activator; neuroprotective\u003c\/td\u003e\n                \u003c\/tr\u003e\n            \u003c\/tbody\u003e\n        \u003c\/table\u003e\n    \u003c\/div\u003e\n\u003c\/div\u003e","brand":"General Peptide","offers":[{"title":"1 Vial","offer_id":50856838627575,"sku":null,"price":47.0,"currency_code":"USD","in_stock":true},{"title":"3 Vials","offer_id":50856838660343,"sku":null,"price":127.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":50856838693111,"sku":null,"price":188.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0934\/1485\/0807\/files\/Cognitive-Neuro_Semax.jpg?v=1781181392","url":"https:\/\/generalpeptide.com\/products\/semax","provider":"General Peptide","version":"1.0","type":"link"}