{"product_id":"nad","title":"NAD+","description":"\u003cdiv class=\"prod-section\"\u003e\n    \u003cdiv class=\"prod-section-label\"\u003e\n        \u003ci class=\"ti ti-file-description\"\u003e\u003c\/i\u003eResearch Background\n    \u003c\/div\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        Nicotinamide Adenine Dinucleotide (NAD+; CAS 53-84-9; MW 663.4 g\/mol; C21H27N7O14P2) is a dinucleotide coenzyme present in every living cell — central to cellular energy metabolism, DNA repair, and cellular signaling. Its inclusion in the General Peptide research catalog reflects the central position NAD+ holds in current aging biology and metabolic research.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        NAD+ serves as the electron carrier in the TCA cycle and oxidative phosphorylation, shuttling electrons as NADH to fuel the mitochondrial electron transport chain for ATP production. The discovery of NAD+ as the rate-limiting substrate for three major enzyme families elevated it to a central position in aging biology: Sirtuins (SIRT1-7) — class III histone deacetylases regulating chromatin remodeling, DNA repair, metabolic gene expression, circadian rhythm maintenance, and mitochondrial biogenesis. SIRT1 and SIRT3 are particularly well-characterized, with loss-of-function associated with accelerated aging phenotypes. Poly(ADP-ribose) polymerases (PARPs) — enzymes that detect DNA damage and initiate repair, consuming NAD+ in the process. DNA damage-induced PARP activation can rapidly deplete cellular NAD+ pools. CD38 and CD157 ADP-ribosyl cyclases — NAD+-consuming enzymes involved in calcium signaling and inflammatory signaling whose expression increases with age and inflammatory states.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        The critical observation is that NAD+ levels decline substantially with age across tissues and species — skeletal muscle, liver, and brain NAD+ content in old animals is 40-60% lower than in young animals. This decline is now understood to be mechanistically linked to multiple aging phenotypes including mitochondrial dysfunction, impaired DNA repair, metabolic syndrome, neurodegeneration, and immunosenescence.\n    \u003c\/p\u003e\n\n    \u003cp class=\"prod-para\"\u003e\n        The 750mg vial format reflects NAD+ use in large-animal and multi-protocol research designs where substantial total quantities are required.\n    \u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"prod-section\"\u003e\n    \u003cdiv class=\"prod-section-label\"\u003e\n        \u003ci class=\"ti ti-atom\"\u003e\u003c\/i\u003ePhysicochemical Data\n    \u003c\/div\u003e\n\n    \u003cdiv class=\"table-scroll\"\u003e\n        \u003ctable class=\"prod-table\"\u003e\n            \u003cthead\u003e\n                \u003ctr\u003e\n                    \u003cth\u003eCompound\u003c\/th\u003e\n                    \u003cth\u003eFormula\u003c\/th\u003e\n                    \u003cth\u003eMW\u003c\/th\u003e\n                    \u003cth\u003eCAS No.\u003c\/th\u003e\n                    \u003cth\u003eSequence \/ Structure\u003c\/th\u003e\n                    \u003cth\u003eReceptor \/ Target\u003c\/th\u003e\n                \u003c\/tr\u003e\n            \u003c\/thead\u003e\n\n            \u003ctbody\u003e\n                \u003ctr class=\"row-alt\"\u003e\n                    \u003ctd class=\"td-bold\"\u003eNAD+\u003c\/td\u003e\n                    \u003ctd\u003eC21H27N7O14P2\u003c\/td\u003e\n                    \u003ctd\u003e663.4 g\/mol\u003c\/td\u003e\n                    \u003ctd\u003e53-84-9\u003c\/td\u003e\n                    \u003ctd\u003eNicotinamide adenine dinucleotide (oxidized form)\u003c\/td\u003e\n                    \u003ctd\u003eCoenzyme; SIRT1-7 substrate; PARP substrate; CD38 substrate; mitochondrial electron carrier\u003c\/td\u003e\n                \u003c\/tr\u003e\n            \u003c\/tbody\u003e\n        \u003c\/table\u003e\n    \u003c\/div\u003e\n\u003c\/div\u003e","brand":"General Peptide","offers":[{"title":"1 Vial","offer_id":50856794685687,"sku":null,"price":46.0,"currency_code":"USD","in_stock":true},{"title":"3 Vials","offer_id":50856794718455,"sku":null,"price":125.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":50856794751223,"sku":null,"price":184.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0934\/1485\/0807\/files\/Longevity_NAD.jpg?v=1781178885","url":"https:\/\/generalpeptide.com\/products\/nad","provider":"General Peptide","version":"1.0","type":"link"}