{"product_id":"cagrilintide-semaglutide","title":"Cagrilintide + Semaglutide","description":"\u003cdiv class=\"prod-section\"\u003e\n\u003cdiv class=\"prod-section-label\"\u003e\n\u003ci class=\"ti ti-file-description\"\u003e\u003c\/i\u003eResearch Background\u003c\/div\u003e\n\u003cp class=\"prod-para\"\u003eThis dual-mechanism metabolic blend combines Cagrilintide (5mg), a long-acting amylin analog targeting amylin receptors to reduce appetite and suppress glucagon, with Semaglutide (5mg), a GLP-1 receptor agonist. Phase II \u003cem\u003eCagriSema\u003c\/em\u003e investigations reported mean body-weight reductions of up to 22.7\u003cstrong\u003e%\u003c\/strong\u003e, compared with 8.0\u003cstrong\u003e%\u003c\/strong\u003e observed with semaglutide alone, while Phase III \u003cem\u003eREDEFINE\u003c\/em\u003e studies continue to evaluate the therapeutic potential of this combination. Dual amylin\/GLP-1 co-agonism has emerged as a major area of interest in next-generation metabolic research.\u003c\/p\u003e\n\u003cp class=\"prod-para\"\u003eCagrilintide is a long-acting amylin analog (MW approximately 3934 g\/mol; CAS 2295591-85-6) engineered with fatty acid conjugation to extend circulation time through albumin binding. Acting as an agonist at amylin receptors (AMY1–3), it mimics endogenous amylin activity by promoting satiety signaling, reducing food intake, and suppressing glucagon release. Its prolonged pharmacokinetic profile supports sustained receptor activation and once-weekly research dosing paradigms.\u003c\/p\u003e\n\u003cp class=\"prod-para\"\u003eSemaglutide is a 29-amino-acid GLP-1 analog (MW 4113.6 g\/mol; CAS 910463-68-6) modified with a C18 fatty diacid side chain that enhances albumin binding and extends biological activity. As a GLP-1 receptor agonist, it stimulates glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and enhances central and peripheral satiety signaling involved in metabolic regulation.\u003c\/p\u003e\n\u003cp class=\"prod-para\"\u003eThe rationale for combining these agents lies in their complementary and potentially synergistic mechanisms. Amylin receptor activation reduces caloric intake through satiety pathways and postprandial glucagon suppression, while GLP-1 receptor activation improves glucose regulation, delays gastric emptying, and further promotes appetite control. Together, these pathways provide a multi-target approach to investigating energy balance, body-weight regulation, and glycemic physiology beyond the effects observed with either mechanism alone.\u003c\/p\u003e\n\u003cdiv class=\"prod-table-wrap\"\u003e\n\u003ctable class=\"prod-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eCompound\u003c\/th\u003e\n\u003cth\u003eMW \/ Formula\u003c\/th\u003e\n\u003cth\u003eCAS No.\u003c\/th\u003e\n\u003cth\u003eSequence \/ Structure\u003c\/th\u003e\n\u003cth\u003eReceptor \/ Target\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eCagrilintide (5mg)\u003c\/td\u003e\n\u003ctd\u003e~3934 g\/mol\u003c\/td\u003e\n\u003ctd\u003e2295591-85-6\u003c\/td\u003e\n\u003ctd\u003eLong-acting amylin analog; fatty acid-conjugated\u003c\/td\u003e\n\u003ctd\u003eAmylin receptor (AMY1–3) agonist; appetite and glucagon regulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSemaglutide (5mg)\u003c\/td\u003e\n\u003ctd\u003e4113.6 g\/mol\u003c\/td\u003e\n\u003ctd\u003e910463-68-6\u003c\/td\u003e\n\u003ctd\u003e29-amino-acid GLP-1 analog with C18 fatty diacid conjugation\u003c\/td\u003e\n\u003ctd\u003eGLP-1 receptor agonist; insulin secretion and appetite regulation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp class=\"prod-note\"\u003e \u003c\/p\u003e\n\u003c\/div\u003e","brand":"General Peptide","offers":[{"title":"1 Vial","offer_id":50856841904375,"sku":null,"price":114.0,"currency_code":"USD","in_stock":true},{"title":"3 Vials","offer_id":50856841937143,"sku":null,"price":308.0,"currency_code":"USD","in_stock":true},{"title":"5 Vials","offer_id":50856841969911,"sku":null,"price":456.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0934\/1485\/0807\/files\/Metabolic_Cagrilintide_Semaglutide.jpg?v=1781181756","url":"https:\/\/generalpeptide.com\/products\/cagrilintide-semaglutide","provider":"General Peptide","version":"1.0","type":"link"}